{"id":161,"date":"2026-02-28T04:34:07","date_gmt":"2026-02-27T20:34:07","guid":{"rendered":"http:\/\/13.115.230.125\/?page_id=161"},"modified":"2026-02-28T05:39:32","modified_gmt":"2026-02-27T21:39:32","slug":"tolvaptan","status":"publish","type":"page","link":"https:\/\/adpkdtw.org\/?page_id=161","title":{"rendered":"Tolvaptan"},"content":{"rendered":"\n

Tolvaptan<\/h1>\n\n\n\n

Tolvaptan \u662f\u4e00\u7a2e\u5354\u52a9\u6291\u5236\u591a\u56ca\u814e\u816b\u56ca\u589e\u52a0\u901f\u5ea6\u7684\u85e5\u7269\u6210\u5206\u3002<\/h3>\n\n\n\n

\u542b\u6709Tolvaptan\u6210\u5206\u7684\u85e5\uff0c\u5fc5\u9808\u7d93\u91ab\u5e2b\u8655\u65b9\uff0c\u8acb\u8a62\u554f\u91ab\u5e2b\u81ea\u5df1\u662f\u5426\u9069\u5408\u4f7f\u7528\u3002<\/p>\n\n\n\n

1) \u591a\u56ca\u814e\u662f\u751a\u9ebc\u75c5?<\/h2>\n\n\n\n

\u591a\u56ca\u814e\u7684\u75c5\u7406<\/h3>\n\n\n\n

\u591a\u56ca\u814e\u662f\u4e00\u7a2e\u907a\u50b3\u6027\u75be\u75c5\uff0c\u814e\u81df\u4e2d\u5f62\u6210\u8a31\u591a\u56ca\u816b\uff08\u5145\u6eff\u6db2\u9ad4\u7684\u888b\u5b50\uff09\uff0c\u56ca\u816b\u9010\u6f38\u8b8a\u5927\u3002\u96a8\u8457\u56ca\u816b\u5728\u814e\u81df\u4e2d\u589e\u52a0\u8b8a\u5927\uff0c\u814e\u81df\u8b8a\u5927\uff0c\u529f\u80fd\u964d\u4f4e\uff0c\u6700\u7d42\u5c0e\u81f4\u814e\u81df\u7121\u6cd5\u6b63\u5e38\u5de5\u4f5c\u3002<\/p>\n\n\n\n

\u70ba\u4ec0\u9ebc\u56ca\u816b<\/h3>\n\n\n\n

\u5982\u679c\u6fc0\u7d20\u201c\u8840\u7ba1\u5347\u58d3\u7d20\uff08\u6297\u5229\u5c3f\u6fc0\u7d20\uff09\u201d\u5728\u591a\u56ca\u814e\u4e2d\u8d77\u4f5c\u7528\uff0c\u56ca\u816b\u5c31\u6703\u8b8a\u5927\u3002\u800c\u7576\u56ca\u816b\u9054\u5230\u4e00\u5b9a\u7684\u5927\u5c0f\uff0c\u814e\u81df\u7684\u529f\u80fd\u5c31\u958b\u59cb\u4e0b\u964d\u3002<\/p>\n\n\n\n

\n
\n
\"\u591a\u56ca\u814e\u7684\u6cbb\u7642-\u670d\u7528\u4f73\u814e\u5eb7\u9320\"<\/figure>\n<\/div>\n\n\n\n
\n
\"\u591a\u56ca\u814e\u7684\u6cbb\u7642-\u670d\u7528\u4f73\u814e\u5eb7\u9320\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

2)\u591a\u56ca\u75c7\u7684\u75c7\u72c0?<\/h2>\n\n\n\n

\u5927\u591a\u6578\u591a\u56ca\u814e\u60a3\u8005\u572830~40\u6b72\u4e4b\u524d\u901a\u5e38\u662f\u6c92\u6709\u75c7\u72c0\u7684\uff0c\u4f46\u96a8\u8457\u56ca\u816b\u589e\u9577\u6703\u51fa\u73fe\u9019\u4e9b\u75c7\u72c0<\/h3>\n\n\n\n
\n
\n
\"\u96a8\u8457\u56ca\u816b\u8b8a\u5927\uff0c\u814e\u819c\u4f38\u5c55\uff0c\u7522\u751f\u80c3\u90e8\u8207\u5074\u8179\u75bc\u75db\u3002<\/figure>\n<\/div>\n\n\n
\n

\u96a8\u8457\u56ca\u816b\u8b8a\u5927\uff0c\u814e\u819c\u4f38\u5c55\uff0c\u7522\u751f\u80c3\u90e8\u8207\u5074\u8179\u75bc\u75db\u3002 \u7d30\u83cc\u611f\u67d3\u56ca\u816b\uff0c\u7522\u751f\u75bc\u75db\u3001\u767c\u71d2\u3001\u80c3\u90e8\u611f\u67d3\uff0c\u5074\u8179\u816b\u8139\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\"\u4ee3\u8b1d\u4f5c\u7528\u5c0e\u81f4\u7684\u56ca\u816b\u58d3\u8feb\uff0c\u548c\u5c3f\u8def\u7d50\u77f3\u5f15\u8d77\u7684\u5c3f\u6d41\u505c\u6eef\u3002\"<\/figure>\n<\/div>\n\n\n
\n

\u4ee3\u8b1d\u4f5c\u7528\u5c0e\u81f4\u7684\u56ca\u816b\u58d3\u8feb\uff0c\u548c\u5c3f\u8def\u7d50\u77f3\u5f15\u8d77\u7684\u5c3f\u6d41\u505c\u6eef\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\n
\n
\"\u814e\u81df\u548c\u809d\u81df\u816b\u8139\u8b8a\u5927\uff0c\u80c3\u7684\u5468\u9577\u8b8a\u5927\u3002\"<\/figure>\n<\/div>\n\n\n
\n

\u814e\u81df\u548c\u809d\u81df\u816b\u8139\u8b8a\u5927\uff0c\u80c3\u7684\u5468\u9577\u8b8a\u5927\u3002<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
\"\u56ca\u816b\u4e2d\u7684\u8840\u7ba1\u7834\u88c2\u800c\u5f15\u8d77\u7684\u8840\u5c3f\u3002\"<\/figure>\n<\/div>\n\n\n
\n

\u56ca\u816b\u4e2d\u7684\u8840\u7ba1\u7834\u88c2\u800c\u5f15\u8d77\u7684\u8840\u5c3f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

3)TOLVAPTAN\u662f\u751a\u9ebc\u85e5?<\/h2>\n\n\n\n

\u85e5\u7684\u5c6c\u6027<\/h3>\n\n\n\n

TOLVAPTAN\u4e0d\u662f\u6cbb\u7642\u591a\u56ca\u814e\u7684\u85e5\u7269\uff0c\u800c\u662f\u4e00\u7a2e\u53ef\u963b\u7919\u814e\u81df\u4e2d\u7684\u201c\u8840\u7ba1\u5347\u58d3\u7d20\u201d\uff0c\u6709\u6548\u6291\u5236\u56ca\u816b\u589e\u9577\u901f\u5ea6\u7684\u85e5\u7269\u3002<\/p>\n\n\n\n

\u6301\u7e8c\u670d\u7528\u8a72\u85e5\uff0c\u6709\u52a9\u65bc\u5ef6\u9072\u814e\u529f\u80fd\u4e0b\u964d\u548c\u814e\u529f\u80fd\u8870\u7aed\u7684\u6642\u9593\u3002\u7531\u65bc\u8840\u7ba1\u5347\u58d3\u7d20\u5177\u6709\u8abf\u7bc0\u5c3f\u91cf\u7684\u529f\u80fd\uff0c\u6240\u4ee5\u670d\u7528\u4f73\u814e\u5eb7\u6703\u589e\u52a0\u5c3f\u91cf\u548c\u5c3f\u7684\u6b21\u6578\u3002<\/p>\n\n\n

\n
\"\u591a\u56ca\u814e\u7684\u6cbb\u7642-\u670d\u7528\u4f73\u814e\u5eb7\u9320\"<\/figure>\n<\/div>\n\n\n

\u885b\u751f\u798f\u5229\u90e8\u8a31\u53ef\u7684\u9069\u61c9\u75c7<\/h3>\n\n\n\n

\u9069\u7528\u65bc\u81ea\u9ad4\u986f\u6027\u591a\u56ca\u6027\u814e\u81df\u75c5(ADPKD)\u4e14eGFR\u5927\u65bc25mL\/min\/1.73m2<\/sup>\u4e4b\u6162\u6027\u814e\u81df\u75c5\u6210\u4eba\u60a3\u8005\uff0c\u5df2\u51fa\u73fe\u75c5\u60c5\u8fc5\u901f\u60e1\u5316\u8de1\u8c61\uff0c\u7528\u4ee5\u5ef6\u7de9\u81ea\u9ad4\u986f\u6027\u591a\u56ca\u6027\u814e\u81df\u75c5\u4e4b\u56ca\u6ce1\u7684\u751f\u9577\u53ca\u814e\u529f\u80fd\u7684\u60e1\u5316\u3002<\/p>\n\n\n\n

\u5168\u6c11\u5065\u5eb7\u4fdd\u96aa\u300c\u85e5\u54c1\u7d66\u4ed8\u898f\u5b9a\u300d<\/h3>\n\n\n\n

2.13.2. Tolvaptan\u00a0<\/h3>\n\n\n\n

1. \u9650\u814e\u81df\u5c08\u79d1\u91ab\u5e2b\u8655\u65b9\uff0c\u9808\u7d93\u4e8b\u524d\u5be9\u67e5\u6838\u51c6\u5f8c\u4f7f\u7528\uff0c\u6bcf\u65e5\u81f3\u591a\u4f7f\u75282\u7c92\uff0c\u6bcf\u5e74\u6aa2\u9644\u8a55\u4f30\u8cc7\u6599\u91cd\u65b0\u7533\u8acb\u3002<\/strong><\/p>\n\n\n\n

2. \u9650\u7528\u65bc\u5df2\u51fa\u73fe\u75c5\u60c5\u8fc5\u901f\u60e1\u5316\u8de1\u8c61\u4e4b\u7b2c3 \u671f\u6162\u6027\u814e\u81df\u75c5\u768418 \u2013 50 \u6b72\u81ea\u9ad4\u986f\u6027\u591a\u56ca\u6027\u814e\u81df\u75c5 (ADPKD) \u60a3\u8005\uff0c\u4e14\u814e\u81df\u5f71\u50cf\u5448\u96d9\u5074\u7030\u6f2b\u6027\u6c34\u6ce1\uff0c\u75c5\u60c5\u9808\u7b26\u5408\u4e0b\u5217\u81f3\u5c11\u4e00\u9805\uff1a<\/strong><\/p>\n\n\n\n

    \n
  • 1) \u4e00\u5e74\u4e4b\u5167eGFR\u4e0b\u964d\u22675.0mL\/min\/1.73 m2<\/sup>\u6216\u4e94\u5e74\u5167eGFR \u6bcf\u5e74\u4e0b\u964d\u22672.5 mL\/min\/1.73 m2<\/sup>\uff0c\u4e14\u6392\u9664\u5176\u5b83\u5982\u812b\u6c34\u3001\u85e5\u7269\u3001\u611f\u67d3\u3001\u963b\u585e\u7b49\u539f\u56e0\u6240\u81f4\u3002<\/li>\n\n\n\n
  • 2) htTKV \u7b26\u5408Mayo \u5206\u671f1C-1E disease<\/li>\n<\/ul>\n\n\n\n

    3. \u75c5\u60a3\u958b\u59cb\u4f7f\u7528tolvaptan \u524d\uff0c\u78ba\u8a8d\u4e0b\u5217\u689d\u4ef6\u53ca\u75c5\u53f2\uff1a<\/strong><\/p>\n\n\n\n

      \n
    1. \u7528\u85e5\u524d\u809d\u529f\u80fd\u6b63\u5e38<\/li>\n\n\n\n
    2. \u8840\u6e05\u5c3f\u9178\u6fc3\u5ea6\u63a7\u5236\u57287mg\/dL \u6216\u4ee5\u4e0b<\/li>\n\n\n\n
    3. \u6c92\u6709\u9752\u5149\u773c\u6216\u7d93\u773c\u79d1\u91ab\u5e2b\u8b49\u660e\u773c\u58d3\u63a7\u5236\u826f\u597d<\/li>\n\n\n\n
    4. \u6c92\u6709\u76ae\u819a\u816b\u7624\u7684\u75c5\u53f2<\/li>\n\n\n\n
    5. \u6c92\u6709\u96fb\u89e3\u8cea\u7570\u5e38<\/li>\n\n\n\n
    6. \u6392\u9664\u61f7\u5b55\u3001\u54fa\u4e73\u3001\u812b\u6c34\u3001\u5c3f\u8def\u963b\u585e\u3001\u53ca\u809d\u81df\u640d\u50b7\u75c5\u53f2<\/li>\n<\/ol>\n\n\n\n

      4. \u51fa\u73fe\u4e0b\u5217\u60c5\u6cc1\u6642\u505c\u7528tolvaptan\uff1a<\/strong><\/p>\n\n\n\n

        \n
      1. \u5728\u85e5\u7269\u8abf\u6574\u5f8c\uff0c\u809d\u529f\u80fd\u6307\u6578\u4ecd\u9ad8\u65bc\u4e0a\u9650\u4e09\u500d<\/li>\n\n\n\n
      2. \u5728\u4f7f\u7528tolvaptan \u4e00\u5e74\u5f8c\uff0ceGFR \u4e0b\u964d\u4ecd\u22675mL\/min\/1.73 m2<\/sup><\/li>\n\n\n\n
      3. \u6709\u660e\u986f\u526f\u4f5c\u7528\u4ee5\u81f4\u6709\u5371\u5bb3\u5065\u5eb7\u7684\u7591\u616e\u6642<\/li>\n<\/ol>\n\n\n\n

        \u670d\u7528\u6642\u7684\u6ce8\u610f\u4e8b\u9805<\/h3>\n\n\n\n

        \u5c3f\u91cf\u6703\u589e\u52a0\uff0c\u4e14\u5bb9\u6613\u53e3\u6e34\u3002\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u8acb\u88dc\u7d66\u6c34\u5206\uff0c\u5982\u679c\u4e0d\u88dc\u5145\u6c34\u5206\uff0c\u53ef\u80fd\u6703\u5c0e\u81f4\u812b\u6c34\u6216\u589e\u52a0\u8840\u6db2\u4e2d\u7684\u9209\u6fc3\u5ea6\uff0c\u5c0e\u81f4\u56b4\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n

        \u6b64\u5916\uff0c\u8acb\u5728\u5c31\u5be2\u524d\u88dc\u51451\uff5e2\u676f\u7684\u6c34\u5206\u3002\u591c\u9593\u6bcf\u6b21\u53bb\u6392\u5c3f\uff0c\u4e5f\u8981\u88dc\u7d66\u6c34\u5206\u3002\u81ea\u5df1\u53ef\u80fd\u6c92\u6709\u6ce8\u610f\u5230\u6709\u812b\u6c34\u7684\u73fe\u8c61\uff0c\u6240\u4ee5\u8981\u8a18\u5f97\u52e4\u65bc\u651d\u53d6\u6c34\u5206\u3002<\/p>\n\n\n\n

        \u670d\u7528\u5f8c\uff0c\u5c3f\u91cf\u589e\u52a0\uff0c\u6703\u7d93\u5e38\u60f3\u8981\u6392\u5c3f\u3002\u6b64\u5916\uff0c\u70ba\u4e86\u6e1b\u5c11\u534a\u591c\u4e0a\u5ec1\u6240\u7684\u6b21\u6578\uff0c\u665a\u4e0a\u7684\u5291\u91cf\u8acb\u81f3\u5c11\u5728\u7761\u524d4\u5c0f\u6642\u670d\u7528\u3002<\/p>\n\n\n\n

        \u88dc\u5145\u6c34\u5206\u6642\uff0c\u8acb\u6ce8\u610f\u4e0d\u8981\u651d\u53d6\u904e\u591a\u7684\u5496\u5561\u56e0\u548c\u7cd6\u5206\u3002\u6cbb\u7642\u4e2d\uff0c\u88dc\u7d66\u7684\u6c34\u5206\u8acb\u7528\u6c34\uff08\u81ea\u4f86\u6c34\u6216\u7926\u6cc9\u6c34\uff09\u3002\u7531\u65bc\u651d\u53d6\u904e\u591a\u5496\u5561\u56e0\u6703\u4f7f\u56ca\u816b\u8b8a\u5927\uff0c\u56e0\u6b64\u8981\u6ce8\u610f\u4e0d\u8981\u98f2\u7528\u904e\u591a\u7684\u8336\u6216\u5496\u5561\u3002<\/p>\n\n\n\n

        \u670d\u7528\u6642\u9700\u6ce8\u610f\u7684\u98f2\u98df<\/h3>\n\n\n\n

        \u8acb\u4e0d\u8981\u8207\u8461\u8404\u67da\u6c41\u4e00\u8d77\u670d\u7528\uff0c\u5982\u679c\u559d\u4e86\u8461\u8404\u67da\u6c41\u53ef\u80fd\u6703\u7522\u751f\u85e5\u7269\u526f\u4f5c\u7528\u3002
        \u5982\u679c\u5fd8\u8a18\u670d\u7528\uff0c\u4e26\u5f88\u5feb\u767c\u73fe\u6642\uff0c\u5247\u8acb\u5118\u5feb\u670d\u7528\u9019\u4e00\u6b21\u7684\u5291\u91cf\u3002
        \u4f46\u662f\uff0c\u5982\u679c\u8207\u63a5\u4e0b\u4f86\u7684\u670d\u7528\u6642\u9593\u63a5\u8fd1\uff0c\u5247\u8acb\u8df3\u904e\u9019\u4e00\u6b21\uff0c\u8acb\u4e00\u5b9a\u4e0d\u8981\u4e00\u6b21\u670d\u75282\u5291\u3002<\/p>\n\n\n\n

        4)\u5176\u4ed6\u9700\u6ce8\u610f\u7684\u4e8b\u9805?<\/h2>\n\n\n\n

        \u61f7\u5b55\u6216\u54fa\u4e73\u4e2d\u7684\u4eba<\/h3>\n\n\n\n

        \u670d\u7528\u85e5\u7269\u53ef\u80fd\u5c0e\u81f4\u80ce\u5152\u7578\u5f62\uff0c\u4e26\u4e14\u85e5\u7269\u7684\u6210\u5206\u6703\u5f9e\u4e73\u6c41\u4e2d\u6ef2\u51fa\u3002\u5982\u679c\u5728\u670d\u7528\u6642\u77e5\u9053\u5df2\u61f7\u5b55\u6216\u5728\u54fa\u4e73\uff0c\u8acb\u8aee\u8a62\u91ab\u751f\u3002<\/p>\n\n\n\n

        \u4e0d\u53ef\u81ea\u884c\u6c7a\u5b9a\u8b93\u5152\u7ae5\u670d\u7528<\/h3>\n\n\n\n

        TOLVAPTAN\u5c0d\u5152\u7ae5\u6709\u7121\u6548\u679c\u9084\u672a\u78ba\u8a8d\u3002\u6b64\u5916\uff0c\u7531\u65bc\u5c3f\u6db2\u589e\u52a0\uff0c\u5152\u7ae5\u53ef\u80fd\u7121\u6cd5\u5145\u5206\u651d\u53d6\u6c34\u5206\uff0c\u5bb9\u6613\u9020\u6210\u5371\u96aa\u6027\u3002 \u5343\u842c\u4e0d\u53ef\u64c5\u81ea\u6c7a\u5b9a\u8b93\u5152\u7ae5\u670d\u7528\u3002<\/p>\n\n\n\n

        \u63a5\u53d7\u5176\u4ed6\u75be\u75c5\u7684\u8a3a\u7642\u6642\uff0c\u8acb\u544a\u77e5\u6b63\u5728\u670d\u7528TOLVAPTAN<\/h3>\n\n\n\n

        \u5728\u670d\u7528TOLVAPTAN\u6642\uff0c\u6709\u540c\u6642\u670d\u7528\u5176\u4ed6\u85e5\u7269\u6216\u88dc\u5145\u5291\uff0cTOLVAPTAN\u7684\u4f5c\u7528\u6709\u6642\u5019\u6703\u5f88\u5f37\u3002<\/p>\n\n\n\n

        \u7576\u63a5\u53d7\u5176\u4ed6\u75be\u75c5\u7684\u8a3a\u7642\u6642\uff0c \u8acb\u4e00\u5b9a\u8981\u544a\u77e5\u91ab\u751f\u548c\u85e5\u5291\u5e2b\u81ea\u5df1\u6b63\u5728\u670d\u7528TOLVAPTAN\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

        Tolvaptan Tolvaptan \u662f\u4e00\u7a2e\u5354\u52a9\u6291\u5236\u591a\u56ca\u814e\u816b\u56ca\u589e\u52a0\u901f\u5ea6\u7684\u85e5\u7269\u6210\u5206\u3002 \u542b\u6709Tolvaptan\u6210 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-161","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/pages\/161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adpkdtw.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=161"}],"version-history":[{"count":8,"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/pages\/161\/revisions"}],"predecessor-version":[{"id":176,"href":"https:\/\/adpkdtw.org\/index.php?rest_route=\/wp\/v2\/pages\/161\/revisions\/176"}],"wp:attachment":[{"href":"https:\/\/adpkdtw.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}